Cerebrospinal Fluid of Patients With Communicating Hydrocephalus After Subarachnoid Hemorrhage
نویسنده
چکیده
Background and Purpose Transforming growth factor-/31 (TGF-/31) is a multifunctional polypeptide that controls the production of extracellular matrix protein. Platelets store a large quantity of TGF-/31, which is released at hemorrhage. We recently reported that human recombinant TGF-/31 induced communicating hydrocephalus in mice. The aim of this study was to determine whether TGF-01 is related to the development of communicating hydrocephalus after subarachnoid hemorrhage (SAH). Methods TGF-01 in the cerebrospinal fluid of 24 patients with SAH was measured with enzyme-linked immunosorbent assay. The levels were compared between hydrocephalic and nonhydrocephalic groups. Western blot analysis was performed to determine active TGF-^1 in the cerebrospinal fluid. Results TGF-/31 rapidly decreased from the onset of SAH. The level of TGF-/31 of 13 patients showing ventricular
منابع مشابه
Cerebrospinal fluid circulation following subarachnoid hemorrhage.
1 33 6 165 Yes 1 yr. Complete recovery Alterations in the cerebrospinal fluid (CSF) cir culation may follow subarachnoid hemorrhage a! though the frequency and extent to which this occurs is unknown. Accurate definition of these abnormali ties is important because in some instances they result in symptomatic communicating hydrocephalus (1 ,2) . Current methods of assessing the patency of the su...
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